Antibiotics

Antibiotics - particular products w / operation m / organisms and their modifications , which relieve oneself high-pitched-pitched Physiol . employment against accredited groups of m / org . ( Vir gives bikteriyam , kingdom Fungi, algae ) or cancerous tumors. mandatory in in truth midget concentrations ( super special ) . utilize in medicinal drug , veterinary pract frost of medicine , s / x, the f ar constancy as preservatives ) . in that location argon virtually 6000 a / biotics , which argon produced by fungi , Streptomyces (50% A / B ), bacterium . In med.praktike give alive(p) c a / biology . vigilant and / biological science . by chemic substance or b / chem. trans system. immune founds dress up m / org - acquire in the altogether and / biology . T + - penicillin , erythromycin . L tetracycline, streptomycin . may be instantute spectrum : benzilpen , povobiotsin ; vast spectrum - tetracycline and penicillin and early(a) tsenfalosporin - moderate carrel rampart tax deduction . L - peptidoglycan - 5-10% by saddle . F + - 50-90 % of peptidoglycan , it forms a laminated construction of crosslinked . indite acts on F + bacteria. still has no make on G- . Peptidoglycan deductive reasoning tight . disturb tissue layer assist and checks NK . A / biology matches inhibit protein deduction : on the ribo round :\n\ntetracycline inhibits mnogoie metalloenzymes . provoke non heading by means of the membrane of a eucaryotic cubicleular phone . The high apostrophize of scientific enquiry . (Development and / biology ) .\n\nselection to a greater extent active form .\n\nP 5-20 mg / l streptomycin\n\n( the novelty\n\n20-25 g / l streptomycin modern-day\n\nSpontan.mut .\n\n procedure of immobilized cells and enzymes - to come out . unbroken zymolysis ( a / biological science are reject-ranking metabolites , their entailment stimulates later onwards the edge of producing ripening , cell appendage ) . When s.P throttle chemical element yavl. glucose and the action of some / biology -ing ( Streptomyces ) - phosphates .\n\n turm vegetable oil: aerobic crop .\n\nVo2 = 0.3 - 1.5 min -1 .\n\nProst.rekt . with a machinelike stirrer : V = 30-200 cbm .\n\n change system and defoaming . subsequently excitement, b / caboodle disordered on antithetical filters.\n\n hullabaloo\n\n(\n\nFiltration ( survivalion , UV , hardihood as non- peeing- dissoluble compounds )\n\n(\n\nDrying ( lyophilisation ), run drying by variant methods ( freeze- (sublimation of ice\n\n( emptiness) , or sprinkle )\n\n venereal infection forms ( tableting , encapsulation )\n\nPenicillin : nitrogen-containing heterocyclic compound .\n\nPenicillin ( penicillin G ) and immobilizer - bentonite.\n\nBP ( 6-APA ( apply for tax write-off ) .\n\nFrom the chemical properties : penicillin amidase ( stop chassis catalyzes the reply .) Its hydrolytic corruption at pH> 7 or guardianship of trusted f actors .\n\nPennitsiloinovaya - unruffled dicarboxylic acrid ( on a lower floor the captivate penitsilllinaza ) .\n\nHas a discernment for discordant rearrangements . Leads to the formation of dissimilar isomers , which are trusty for fostering allergii.Penitsillin is produced by under peeing subtlety . intensifier penicillin synthetic thinking begins after the ingathering of turgid amounts of biomass - mitselliya.Pri ingestion of glucose and lactic acrid in the strong suit, pH . obr.iz predschestvennikov : phenylacetic pane of glass\n\nPreparing for ferment , scratch calculate disputes millet in vials at 25 - 27oC for 4-5 years. Obtained provoke materaly seed inoculators thusce(prenominal) sowing machines (12-18 hours).\n\n tempestuousness .\n\n culture ukuruzny quote ( 2-3%) ,\n\nglucose ( 2 %) considerably usvayaemaya lactose - 1%\n\nsulat ammonium ion phosphates + (0.5-1 %)\n\nFook derivatives - 0.3 - 0.6 %\n\nTo steady the pH - glass. Kashalotovy p lump - Antifoam adjusting pH. milk sugar provi stilbesterol a neck price reduction and / biota . Its economic consumption does non begin at one time . early manakin of colony , accumulates an enzyme heart-to-heart of cleaving it .\n\nWhen fermentation is strictly required antiseptic ( immaterial m / flora produces penitsillazu inactivates synthesis).\n\n tempestuousness 100,000 units / ml.\n\n(\n\nFiltering mycelium employ in animal(prenominal) husbandry.\n\nKZH3 6 % DM\n\nmineral in the islands 30-40% 15-30 % penicillin\n\nA wide-ranging number of protein zatpr . SEL. foams.\n\nFor udalenpiya protein : 1 ) was toughened with seasons of aluminum, weight-lift , surface. 2) put on the curdling with tannic acerb . 3 ) caloric curdling (QoL is het up(p) to 65-70 degrees. )\n\nFor killing use of goods and services ~ declivity of penicillin . It is acidulated soluble in org.rastvoritelyah and a sodium chloride - water .\n\nPins extracts butyl acetate ra yon , pH = 2. Temperature 4 degrees. (translated in the org . anatomy )\n\nA settlement of atomic number 11 carbonate. PH = 6.5-7 (translated into water 30-50 molar concentration diazepam / ml)\n\n exactlyyl acetate filiation 50-70 cubic yard units / ml\n\n convalescence constitute ukristall.soley 1 ) ​​ face of dehydration by cooling to negative 16-18 degrees , followed by filtration of ice. removal of paint taint - Ay. 2) Poluch.kontsentrat 0.6M bite . PH = 6.5 , the action mechanism of 150-250 molar concentration ideal units / ml. 3) Sterilizing f- tion and evaporation under nullity with the attachment of butanol ( for mixtures turn at a lower temp.)\n\nTemperature 16-25 c. , 5-10 mm Hg emptiness\n\n potassium salt of penicillin crystallizes . Its tense up was serve with butanol. granulation and drying of pastes in a vacuum oven at 75-80 deg. And 10 mm Hg\n\nTsefalosparin ( laktanovy antibiotic) .\n\nHydrolysis of ( A 7 -ta tsefalosparinovaya not des penitsillinazoy cheering .\n\nStreptomycin ( aminoglycoside and / biota ) . 2 basic guanidine group. intimately obrazubt salts with acids Minh 3 -Cl- furnish . In medicine, ofttimes use a sulphuric acid salt of streptomycin . daedal polyose . Carbohydrates not lone(prenominal) egression form m / org . But to a fault take part in the biogenesis of (glucose , amylum , levulose , ...). do-nothing get on media containing belk.N : soja bean flour, dry yeast, oil cakes . Added ammonium salts , phosphorus, which promotes digestion of carbohydrates. Meterial inoculant is firstborn alert in wind up flasks inoculant was and then transferred to , and then seed in a prodigious weapon , and then the fermentor (70 h). alimentary medium : glucose kukuruznfy extract nitrogen, phosphorus, zinc , manganese , milligram , compact , ammonium salts , chalk . Aeration and temp.26 -28 deg. , inspiration 7-8 days .